BI-6C9 |
| Catalog No.GC41252 |
BI-6C9는 고도로 특이적인 BH3 상호작용 도메인(Bid) 억제제로 미토콘드리아 외막 전위(MOMP)와 미토콘드리아 분열을 방지하고 미토콘드리아 세포사멸 유도 인자(AIF) 방출과 뉴런의 카스파제-비의존적 세포 사멸로부터 세포를 보호합니다. 1].
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 791835-21-7
Sample solution is provided at 25 µL, 10mM.
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BH3-interacting domain (Bid) is cleaved by caspase-8 to produce the truncated protein tBid, which facilitates cytochrome c release from mitochondria and drives apoptosis. BI-6C9 is an inhibitor of tBid (Kd = 20 µM), blocking the release of both cytochrome c and second mitochondria-derived activator of caspase from mitochondria. It prevents apoptosis in neurons treated with glutamate or oxygen-glucose deprivation. BI-6C9 (10 µM) also inhibits the nuclear translocation of apoptosis-inducing factor AIF, preventing the death of ovarian OVCAR-3 cancer cells induced by IFN-α2a.
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