For blood gas and whole-blood electrolyte investigations, D-phenylalanyl-L-prolyl-L-arginine chloromethyl ketone (PPACK), a selective thrombin inhibitor, was assessed as a potential substitute anticoagulant for lithium heparin (LiHep).

LPS from members of the Enterobacteriaceae family has undergone structural analysis，

Cefiderocol is an antibiotic that is prescribed to treat severe urinary tract infections when no other treatment alternatives are available. It is marketed under the trade name Fetroja among others.

With a human LPA1Kb of 6.9 nM, the oxycyclohexyl acid BMS-986278 is a strong antagonist of the lysophosphatidic acid receptor 1 (LPA1). We present the structure–activity relationship (SAR) research that began with the therapeutic drug BMS-986020 (1), an LPA1 antagonist, and ended with the discovery of BMS-986278. BMS-986278's comprehensive preclinical pharmacology profiles in vitro and in vivo, along with its pharmacokinetics and metabolic profile, are explained. It was advanced into clinical trials, including an ongoing Phase 2 clinical trial in patients with lung fibrosis, on the basis of its in vivo efficacy in rodent chronic lung fibrosis models and excellent overall ADME (absorption, distribution, metabolism, excretion) properties in multiple preclinical species.

With a high selectivity for mitochondria in living cells, IRAZOLVE-MITO (iridium complexed with cyclometalated 2-phenylpyridine and the 5-(5-(4-cyanophen-1-yl) pyrid-2-yl)tetrazolate ligand) exhibits an emission spectrum in the 505–625 nm range 22. In contrast to organic fluorophores,