BSJ-04-132 |
| Catalog No.GC50614 |
BSJ-04-132는 Cereblon 및 CDK용 리간드로 연결된 PROTAC입니다. BSJ-04-132는 강력하고 선택적인 리보시클립 기반 CDK4 분해제(PROTAC)로, CDK4/D1 및 CDK6/D1에 대해 IC50이 각각 50.6nM 및 30nM입니다. BSJ-04-132는 CDK6 및 IKZF1/3 분해를 유도하지 않습니다. BSJ-04-132는 항암 활성이 있습니다.
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Cas No.: 2349356-39-2
Sample solution is provided at 25 µL, 10mM.
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Selective Cdk4 degrader. Degrades Cdk4 in Molt-4 cells, with no effect on Cdk6 levels. Displays cereblon-dependent degradation.
Jiang et al (2019) Development of dual and selective degraders of cyclin-dependent kinases 4 and 6. Angew.Chem.Int.Ed.Engl. 58 6321 PMID:30802347
Average Rating: 5 (Based on Reviews and 24 reference(s) in Google Scholar.)
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