Mensacarcin |
| Catalog No.GC47620 |
고도로 복잡한 폴리케타이드인 멘사카르신은 암세포주에서 보편적으로 세포 성장을 강력하게 억제하고 흑색종 세포에서 세포자멸사를 강력하게 유도합니다. 멘사카르신은 미토콘드리아를 표적으로 하고, 미토콘드리아의 에너지 대사에 영향을 미치고, 카스파제 의존적 세포자멸사 경로를 활성화합니다. 항생제인 멘사카르신은 항체-약물 접합체(ADC)의 세포독성 성분으로 사용될 수 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 808750-39-2
Sample solution is provided at 25 µL, 10mM.
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Mensacarcin is a bacterial metabolite that has been found in S. bottropensis and has anticancer activity.1,2 It is cytostatic in the NCI-60 panel of cancer cell lines (mean IC50 = 1.3 µM) and cytotoxic to HepG2, HM02, KATO III, and MCF-7 cells (IC50s = 0.4-50 µM).1 Mensacarcin induces apoptosis in SK-MEL-28 and SK-MEL-5 melanoma cells.2
1.Maier, S., PflÜger, T., Loesgen, S., et al.Insights into the bioactivity of mensacarcin and epoxide formation by MsnO8Chembiochem15(5)749-756(2014) 2.Plitzko, B., Kaweesa, E.N., and Loesgen, S.The natural product mensacarcin induces mitochondrial toxicity and apoptosis in melanoma cellsJ. Biol. Chem.292(51)21102-21116(2017)
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