CAY10739 |
| Catalog No.GC41494 |
CAY10739는 선택적 S1PR1 억제제로 pIC50이 7.6이고 선택성이 다른 S1PR 동형 S1PR2/3/4에 비해 >40배 및 >80배입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2328109-05-1
Sample solution is provided at 25 µL, 10mM.
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CAY10739 is a soft-drug agonist of the sphingosine-1-phosphate receptor 1 (S1P1; IC50 = 25.12 nM in a β-arrestin recruitment assay) that was designed to prevent systemic effects following topical application. It is selective for S1P1 over S1P2, S1P3, and S1P4 (IC50s = 1,000, >10,000, >10,000 nM, respectively, in a β-arrestin recruitment assay). In human S9 skin subcellular fractions, an ester group that protects an unstable phenol group is cleaved to release the active soft drug. The active soft drug and its nonenzymatically formed isomers are rapidly metabolized in isolated human hepatocytes.
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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