IBR2 |
| Catalog No.GC32912 |
IBR2는 강력하고 특이적 RAD51 억제제이며 RAD51 매개 DNA 이중 가닥 파손 복구를 억제합니다. IBR2는 RAD51 다량체화를 방해하고, 프로테아좀 매개 RAD51 단백질 분해를 가속화하고, 암세포 성장을 억제하고, 세포자멸사를 유도합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 313526-24-8
Sample solution is provided at 25 µL, 10mM.
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IBR2 is a specific RAD51 inhibitor.
IBR2 shows interesting RAD51 inhibition activities. RAD51 is rapidly degraded in IBR2-treated cancer cells, and the homologous recombination repair is impaired, subsequently leading to cell death. The IC50 values of the original IBR2 are in the range of 12-20 µM for most tested cancer cell lines. IBR2 can inhibit the growth of triple-negative human breast cancer cell line MBA-MD-468 with an IC50 of 14.8 µM[1].
[1]. Zhu J, et al. Synthesis, molecular modeling, and biological evaluation of novel RAD51 inhibitors. Eur J Med Chem. 2015;96:196-208.
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