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Conglobatin

Catalog No.GC18832 Copy One-Click Copy Product Info

Conglobatin is a dimeric macrolide dilactone originally isolated from S.

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Conglobatin Chemical Structure

Cas No.: 72263-05-9

Size 가격 재고 수량
500μg
US$313.00
재고 있음
2.5mg
US$1,408.00
재고 있음

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고객 리뷰

Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.



Description of Conglobatin

Conglobatin is a dimeric macrolide dilactone originally isolated from S. conglobatus. It disrupts binding of heat shock protein 90 (Hsp90) to the co-chaperone Cdc37 complex and induces downregulation of client protein expression in SK-BR-3 breast cancer cells. It also inhibits cell proliferation in HER2+ breast cancer cell lines (IC50s = 12.9-61.5 uM, respectively) and decreases the number of invasive cells in vitro. When combined with lapatinib , tumor growth of SK-BR-3 mouse xenografts was reduced to a greater degree than with conglobatin alone. Conglobatin has various anticancer effects in esophageal squamous cell carcinoma (ESCC) models as well, including an inhibition of cell proliferation in KYSE510 cells (IC50 = 9.31 uM). It also inhibits β1 integrin activation leading to a loss of cellular adhesion.

Chemical Properties of Conglobatin

Cas No. 72263-05-9 SDF
Chemical Name (3E,5R,11E)-3,5,7S,11,13R,15S-hexamethyl-8S,16S-bis(5-oxazolylmethyl)-1,9-dioxacyclohexadeca-3,11-diene-2,10-dione
Canonical SMILES C[C@H]([C@H](CC1=CN=CO1)OC(/C(C)=C/[C@H](C)C[C@H](C)[C@H](CC2=CN=CO2)O3)=O)C[C@@H](C)/C=C(C)\C3=O
Formula C28H38N2O6 M.Wt 498.6
Solubility DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Conglobatin

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1 mg 5 mg 10 mg
1 mM 2.0056 mL 10.0281 mL 20.0562 mL
5 mM 401.1 μL 2.0056 mL 4.0112 mL
10 mM 200.6 μL 1.0028 mL 2.0056 mL
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In vivo Formulation Calculator (Clear solution) of Conglobatin

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

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Review for Conglobatin

Average Rating: 5 ★★★★★ (Based on Reviews and 36 reference(s) in Google Scholar.)

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