Samuraciclib hydrochloride (ICEC0942 hydrochloride) (Synonyms: CT7001 hydrochloride; ICEC0942 hydrochloride) |
| Catalog No.GC32735 |
CT7001 염산염(ICEC0942 염산염)(CT7001 염산염)은 IC50이 41nM인 강력하고 선택적이며 ATP 경쟁적이며 경구 활성인 CDK7 억제제입니다. CT7001 염산염(ICEC0942 염산염)은 CDK1, CDK2(IC50 578nM), CDK5 및 CDK9에 대해 각각 45배, 15배, 230배 및 30배 선택성을 나타냅니다. CT7001 염산염(ICEC0942 염산염)은 0.2-0.3 사이의 GI50 값으로 유방암 세포주의 성장을 억제합니다. μM. CT7001 염산염(ICEC0942 염산염)은 항종양 효과가 있습니다.
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Cas No.: 1805789-54-1
Sample solution is provided at 25 µL, 10mM.
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CT7001 hydrochloride is a selective CDK7 inhibitor, with IC50s of 41 nM and 578 nM for CDK7/CycH/MAT1 and CDK2/cycE1, respectively.
CT7001 (ICEC0942) is a selective CDK7 inhibitor, with IC50s of 41 nM and 578 nM for CDK7/CycH/MAT1 and CDK2/cycE1, respectively[1].
[1]. Hazel P, et al. Inhibitor Selectivity for Cyclin-Dependent Kinase 7: A Structural, Thermodynamic, and Modelling Study. ChemMedChem. 2017 Mar 7;12(5):372-380.
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