Samuraciclib hydrochloride (ICEC0942 hydrochloride) (Synonyms: CT7001 hydrochloride; ICEC0942 hydrochloride) |
| Katalog-Nr.GC32735 |
CT7001-Hydrochlorid (ICEC0942-Hydrochlorid) (CT7001-Hydrochlorid) ist ein potenter, selektiver, ATP-kompetitiver und oral aktiver CDK7-Inhibitor mit einem IC50-Wert von 41 nM. CT7001-Hydrochlorid (ICEC0942-Hydrochlorid) zeigt eine 45-, 15-, 230- und 30-fache SelektivitÄt gegenÜber CDK1, CDK2 (IC50 von 578 nM), CDK5 bzw. CDK9. CT7001-Hydrochlorid (ICEC0942-Hydrochlorid) hemmt das Wachstum von Brustkrebs-Zelllinien mit GI50-Werten zwischen 0,2-0,3 μM. CT7001-Hydrochlorid (ICEC0942-Hydrochlorid) hat Anti-Tumor-Wirkungen.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1805789-54-1
Sample solution is provided at 25 µL, 10mM.
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CT7001 hydrochloride is a selective CDK7 inhibitor, with IC50s of 41 nM and 578 nM for CDK7/CycH/MAT1 and CDK2/cycE1, respectively.
CT7001 (ICEC0942) is a selective CDK7 inhibitor, with IC50s of 41 nM and 578 nM for CDK7/CycH/MAT1 and CDK2/cycE1, respectively[1].
[1]. Hazel P, et al. Inhibitor Selectivity for Cyclin-Dependent Kinase 7: A Structural, Thermodynamic, and Modelling Study. ChemMedChem. 2017 Mar 7;12(5):372-380.
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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