DNMDP |
| Catalog No.GC62234 |
포스포디에스테라제 3A(PDE3A) 억제제인 DNMDP는 강력하고 선택적인 암세포 세포독성제입니다. PDE3A에 대한 DNMDP 결합은 PDE3A와 Schlafen 12(SLFN12) 간의 상호작용을 촉진합니다. DNMDP는 명확한 세포 선택적 세포 독성을 보여줍니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 328104-79-6
Sample solution is provided at 25 µL, 10mM.
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DNMDP, a phosphodiesterase 3A (PDE3A) inhibitor, is a potent and selective cancer cell cytotoxic agent. DNMDP binding to PDE3A promotes an interaction between PDE3A and Schlafen 12 (SLFN12). DNMDP shows clear cell-selective cytotoxicity[1].
DNMDP (0-1000 μM; 48 hours) shows clear cell-selective cytotoxicity[1]. HeLa cells undergo apoptosis upon DNMDP treatment, indicates by caspase activity detected by a caspase-sensitive luciferase assay and by poly ADP ribose polymerase (PARP) cleavage. At a concentration of 100 nM, DNMDP specifically inhibits both PDE3A and PDE3B, weakly inhibits PDE10, and had little or no detectable effect on other phosphodiesterases[1].
[1]. de Waal L, et al. Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics. Nat Chem Biol. 2016 Feb;12(2):102-8.
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