E3 ligase Ligand 8 hydrochloride |
| Catalog No.GC34565 |
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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E3 ligase Ligand 8 hydrochloride (compound 24) is a Ligand of BET for E3 Ligase used in PROTAC, with IC50 values of 0.98 nM and 13.7 nM in RS4;11 and MOLM-13 cells, respectively[1]. E3 ligase[1].
[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.
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