Fesoterodine Fumarate (Synonyms: SMP 8272, SPM 907) |
| Catalog No.GC16087 |
Fesoterodine Fumarate는 M1, M2, M3, M4, M5 수용체에 대한 pKi 값이 각각 8.0, 7.7, 7.4, 7.3, 7.5인 경구 활성 비아형 선택적 경쟁적 무스카린 수용체(mAChR) 길항제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 286930-03-8
Sample solution is provided at 25 µL, 10mM.
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Fesoterodine Fumarate is an antimuscarinic agent and is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine that is a muscarinic receptor antagonist.IC50 value:Target: mAChRFesoterodine has the advantage of allowing more flexible dosage than other muscarinic antagonists. Its tolerability and side effects are similar to other muscarinic antagonists and as a new drug seems unlikely to make great changes in practices of treatment for overactive bladder.
References:
[1]. Staskin David; Khullar Vik; Michel Martin C et al. Effects of voluntary dose escalation in a placebo-controlled, flexible-dose trial of fesoterodine in subjects with overactive bladder. Neurourology and urodynamics (2011), 30(8), 1480-5.
[2]. Vella Maria; Cardozo Linda Review of fesoterodine. Expert opinion on drug safety (2011), 10(5), 805-8.
[3]. Malhotra Bimal; Alvey Christine; Gong Jason et al. Effects of fesoterodine on the pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers. British journal of clinical pharmacology (2011), 72(2), 257-62.
[4]. Michel MC. Fesoterodine: a novel muscarinic receptor antagonist for the treatment of overactive bladder syndrome. Expert Opin Pharmacother. 2008 Jul;9(10):1787-96.
[5]. Fesoterodine
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