(E)-Ferulic acid |
| Catalog No.GC34980 |
(E)-Ferulic acid는 식물 세포벽에 풍부한 방향족 화합물인 Ferrulic acid의 이성질체입니다. (E)-페룰린산은 β-카테닌의 인산화를 일으켜 β-카테닌의 프로테아좀 분해를 유발하고 pro-apoptotic factor Bax의 발현을 증가시키고 pro-survivin 인자 survivin의 발현을 감소시킨다. (E)-페룰산은 활성산소종(ROS)을 제거하고 지질 과산화를 억제하는 강력한 능력을 보여줍니다. (E)-Ferulic acid는 인간 폐암 세포주 H1299에서 항증식 및 항이동 효과를 모두 발휘합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 537-98-4
Sample solution is provided at 25 µL, 10mM.
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(E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299[1]. Bax
[1]. Fong Y, et al. Inhibitory effect of trans-ferulic acid on proliferation and migration of human lung cancer cells accompanied with increased endogenous reactive oxygen species and β-catenin instability. Chin Med. 2016 Oct 1;11:45.
| Cas No. | 537-98-4 | SDF | |
| Canonical SMILES | O=C(O)/C=C/C1=CC=C(O)C(OC)=C1.[E] | ||
| Formula | C10H10O4 | M.Wt | 194.18 |
| Solubility | DMSO: 100 mg/mL (514.99 mM) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 5.1499 mL | 25.7493 mL | 51.4986 mL |
| 5 mM | 1.03 mL | 5.1499 mL | 10.2997 mL |
| 10 mM | 0.515 mL | 2.5749 mL | 5.1499 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)
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