α-Bisabolol (Synonyms: DL-α-Bisabolol) |
| Catalog No.GC35305 |
α-비사보롤은 천연 에센셜 오일에 존재하는 무독성 세스퀴테르펜 알코올로 항암 활성이 있습니다. α-Bisabolol은 세포 주기 정지, 미토콘드리아 세포 사멸 유도 및 PI3K/Akt 신호 전달 경로 억제를 통해 A549 NSCLC 세포(IC50=15 μM)에 선택적 항암 효과를 발휘합니다. α-Bisabolol은 또한 신경교종 세포에서 세포자멸사를 강력하게 유도합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 515-69-5
Sample solution is provided at 25 µL, 10mM.
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alpha-Bisabolol is a nontoxic sesquiterpene alcohol present in natural essential oil, with anticancer activity. alpha-Bisabolol exerts selective anticancer effect on A549 NSCLC cells (IC50=15 μM) via induction of cell cycle arrest, mitochondrial apoptosis and inhibition of PI3K/Akt signalling pathways. alpha-Bisabolol also strongly induces apoptosis in glioma cells[1][2].
[1]. Wu S, et al. Anticancer effects of α-Bisabolol in human non-small cell lung carcinoma cells are mediated via apoptosis induction, cell cycle arrest, inhibition of cell migration and invasion and upregulation of P13K/AKT signalling pathway. J BUON. 2018 Sep-Oct;23(5):1407-1412. [2]. Cavalieri E, et al. alpha-Bisabolol, a nontoxic natural compound, strongly induces apoptosis in glioma cells. Biochem Biophys Res Commun. 2004 Mar 12;315(3):589-94.
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