BIIL-260 hydrochloride |
| Catalog No.GC35517 |
BIIL-260 염산염은 강력하고 오래 지속되는 경구 활성 류코트리엔 B(4) 수용체 LTB4 길항제로서 항염 작용을 합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 192581-24-1
Sample solution is provided at 25 µL, 10mM.
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BIIL-260 hydrochloride is a potent and long-acting orally active leukotriene B(4) receptor LTB4 antagonist, with anti-inflammatory activity. BIIL-260 hydrochloride interacts with the LTB4 receptor in a saturable, reversible, and competitive manner, has high affinity to the LTB4 receptor on isolated human neutrophil cell membranes with Ki values of 1.7 nM[1]. Ki: 1.7 nM (LTB4 receptor)[1]
BIIL-260 hydrochloride potently inhibits LTB4-induced intracellular Ca2+ release in human neutrophils with IC50 value of 0.82 nM
[1]. Birke FW, et al. In vitro and in vivo pharmacological characterization of BIIL 284, a novel and potent leukotriene B(4) receptor antagonist. J Pharmacol Exp Ther. 2001 Apr;297(1):458-66.
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