CLP290 |
| Catalog No.GC35713 |
CLP290은 뉴런 특이적 K+-Cl- 공동수송체 KCC2의 경구 사용 가능한 활성제로, 광범위한 신경 및 정신병 징후의 치료 가능성을 보여줍니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1181083-81-7
Sample solution is provided at 25 µL, 10mM.
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CLP290 is an orally available activator of the neuron-specific K+-Cl- cotransporter KCC2, displays potential for treatment of a wide range of neurological and psychiatric indications. CLP290 can significantly lower blood arginine-vasopressin (AVP) and glucose levels in STZ rats[1][2]. KCC2[1]
[1]. Ferrini F, et al. Enhancing KCC2 function counteracts morphine-induced hyperalgesia. Sci Rep. 2017 Jun 20;7(1):3870. [2]. Gagnon M, et al. Chloride extrusion enhancers as novel therapeutics for neurological diseases. Nat Med. 2013 Nov;19(11):1524-8. [3]. Kim YB, et al. Excitatory GABAergic Action and Increased Vasopressin Synthesis in Hypothalamic Magnocellular Neurosecretory Cells Underlie the High Plasma Level of Vasopressin in Diabetic Rats. Diabetes. 2018 Mar;67(3):486-495.
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)
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