CLP290 |
| Katalog-Nr.GC35713 |
CLP290 ist ein oral verfÜgbarer Aktivator des neuronenspezifischen K+-Cl--Cotransporters KCC2 und zeigt Potenzial fÜr die Behandlung einer Vielzahl von neurologischen und psychiatrischen Indikationen.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1181083-81-7
Sample solution is provided at 25 µL, 10mM.
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CLP290 is an orally available activator of the neuron-specific K+-Cl- cotransporter KCC2, displays potential for treatment of a wide range of neurological and psychiatric indications. CLP290 can significantly lower blood arginine-vasopressin (AVP) and glucose levels in STZ rats[1][2]. KCC2[1]
[1]. Ferrini F, et al. Enhancing KCC2 function counteracts morphine-induced hyperalgesia. Sci Rep. 2017 Jun 20;7(1):3870. [2]. Gagnon M, et al. Chloride extrusion enhancers as novel therapeutics for neurological diseases. Nat Med. 2013 Nov;19(11):1524-8. [3]. Kim YB, et al. Excitatory GABAergic Action and Increased Vasopressin Synthesis in Hypothalamic Magnocellular Neurosecretory Cells Underlie the High Plasma Level of Vasopressin in Diabetic Rats. Diabetes. 2018 Mar;67(3):486-495.
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)
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