Foliglurax (Synonyms: PXT002331) |
| Catalog No.GC36064 |
Foliglurax(PXT002331)는 EC50이 79nM인 매우 선택적이고 강력한 뇌 침투 대사성 글루타메이트 수용체 4 양성 알로스테릭 조절제(mGluR4 PAM)입니다.
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Cas No.: 1883329-51-8
Sample solution is provided at 25 µL, 10mM.
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Foliglurax (PXT002331) is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) with an EC50 of 79 nM[1]. Antiparkinsonian effect[1]. mGlu4|79 nM (EC50)
Foliglurax, a highly selective and potent mGlu4 receptor PAM with a marked brain-penetrance feature, might revolutionize the field of mGlu4 receptor drug targeting in CNS disorders[2].
[1]. Charvin D, et al. Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4. J Med Chem. 2017 Oct 26;60(20):8515-8537. [2]. Volpi C, et al. Opportunities and challenges in drug discovery targeting metabotropic glutamate receptor 4. Expert Opin Drug Discov. 2018 May;13(5):411-423.
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
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