Foliglurax (Synonyms: PXT002331) |
| Katalog-Nr.GC36064 |
Foliglurax (PXT002331) ist ein hochselektiver und potenter, das Gehirn durchdringender metabotroper Glutamatrezeptor 4 positiver allosterischer Modulator (mGluR4 PAM) mit einem EC50 von 79 nM.
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Cas No.: 1883329-51-8
Sample solution is provided at 25 µL, 10mM.
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Foliglurax (PXT002331) is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) with an EC50 of 79 nM[1]. Antiparkinsonian effect[1]. mGlu4|79 nM (EC50)
Foliglurax, a highly selective and potent mGlu4 receptor PAM with a marked brain-penetrance feature, might revolutionize the field of mGlu4 receptor drug targeting in CNS disorders[2].
[1]. Charvin D, et al. Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4. J Med Chem. 2017 Oct 26;60(20):8515-8537. [2]. Volpi C, et al. Opportunities and challenges in drug discovery targeting metabotropic glutamate receptor 4. Expert Opin Drug Discov. 2018 May;13(5):411-423.
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