Kinase inhibitor-1 |
| 카탈로그 번호: GC36392 |
Tarloxotinib의 활성 대사산물인 Kinase inhibitor-1은 비가역적 pan-ErbB TKI(Kinase inhibitor-1)입니다.
Sample solution is provided at 25 µL, 10mM.
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Kinase inhibitor-1 (Compound 5) is a kinase inhibitor[1]. Kinase[1]
Kinases represent a large family of enzymes that catalyse the phosphorylation of proteins, lipids and metabolites and play a central role in the regulation of a wide variety of cellular processes. Abnormal kinase activity has been related to a wide range of disorders, including cancers[1].
[1]. Jeffrey Bruce Smaill, et al. Kinase inhibitors, prodrug forms thereof and their use in therapy. US9101632B2.
| Cas No. | 2135696-72-7 | SDF | |
| Canonical SMILES | BrC1=C(Cl)C=CC(NC2=NC=NC3=CN=C(NC(/C=C/CN(C)C)=O)C=C32)=C1 | ||
| Formula | C19H18BrClN6O | M.Wt | 461.74 |
| 용해도 | DMSO: 100 mg/mL (216.57 mM); Water: < 0.1 mg/mL (insoluble) | Storage | Store at -20°C |
| 일반적인 팁 | 높은 용해도를 얻기 위해 튜브를 37℃에서 데운 후 초음파 욕조에서 잠시 흔들어 주십시오. 원액은 -20℃ 이하에서 수개월간 보관할 수 있습니다. | ||
| 배송 조건 | 평가 샘플 솔루션: 블루아이스와 함께 배송합니다. 다른 모든 가능한 크기: 요청 시 RT 또는 블루아이스와 함께 배송합니다. | ||
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
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