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Kinase inhibitor-1

카탈로그 번호: GC36392

Tarloxotinib의 활성 대사산물인 Kinase inhibitor-1은 비가역적 pan-ErbB TKI(Kinase inhibitor-1)입니다.

Kinase inhibitor-1 화학 구조

Size 가격 재고 수량
10mM (in 1mL DMSO)
재고 있음
재고 있음

고객 리뷰

고객 리뷰를 기반으로 합니다.

전화: (626) 353-8530 이메일 주소: sales@glpbio.com

Sample solution is provided at 25 µL, 10mM.

Product Documents

품질 관리 및 안전 데이터 시트

현재 배치 보기


Kinase inhibitor-1 (Compound 5) is a kinase inhibitor[1]. Kinase[1]

Kinases represent a large family of enzymes that catalyse the phosphorylation of proteins, lipids and metabolites and play a central role in the regulation of a wide variety of cellular processes. Abnormal kinase activity has been related to a wide range of disorders, including cancers[1].

[1]. Jeffrey Bruce Smaill, et al. Kinase inhibitors, prodrug forms thereof and their use in therapy. US9101632B2.

화학적 특성

Cas No. 2135696-72-7 SDF
Canonical SMILES BrC1=C(Cl)C=CC(NC2=NC=NC3=CN=C(NC(/C=C/CN(C)C)=O)C=C32)=C1
Formula C19H18BrClN6O M.Wt 461.74
용해도 DMSO: 100 mg/mL (216.57 mM); Water: < 0.1 mg/mL (insoluble) Storage Store at -20°C
일반적인 팁 높은 용해도를 얻기 위해 튜브를 37℃에서 데운 후 초음파 욕조에서 잠시 흔들어 주십시오. 원액은 -20℃ 이하에서 수개월간 보관할 수 있습니다.
배송 조건 평가 샘플 솔루션: 블루아이스와 함께 배송합니다. 다른 모든 가능한 크기: 요청 시 RT 또는 블루아이스와 함께 배송합니다.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % saline

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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**원액을 준비할 때는 항상 바이알 라벨과 MSDS/CoA(온라인에서 사용 가능)에 있는 제품의 배치별 분자량을 사용하십시오.



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Average Rating: 5 ★★★★★ (Based on Reviews and 6 reference(s) in Google Scholar.)

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