Masupirdine free base (Synonyms: SUVN-502 free base) |
| Catalog No.GC36548 |
Masupirdine 유리 염기(SUVN-502 유리 염기)는 강력하고 선택적이고 경구 생체이용 가능한 뇌 침투성 5-HT6 수용체 길항제입니다(인간 5-HT6 수용체의 경우 2.04 nM의 Ki).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 701205-60-9
Sample solution is provided at 25 µL, 10mM.
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Masupirdine free base (SUVN-502 free base) is a potent, selective, orally bioavailable, and brain penetrant 5-HT6 receptor antagonist (Ki of 2.04 nM for human 5-HT6 receptor). Masupirdine free base (SUVN-502 free base) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's disease[1]. Ki: 2.04 nM (human 5-HT6 receptor)[1]
[1]. Nirogi R, et al. Discovery and Development of 1-[(2-Bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole Dimesylate Monohydrate (SUVN-502): A Novel, Potent, Selective and Orally Active Serotonin 6 (5-HT6) Receptor Antagonist for Potential Treatment of Alzheimer's Disease. J Med Chem. 2017 Mar 9;60(5):1843-1859.
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
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