Pozanicline (Synonyms: ABT-089) |
| Catalog No.GC36952 |
포자니클린(ABT-089)은 신경 니코틴성 아세틸콜린 수용체(nAChR) 하위 유형을 선택적으로 활성화하며, α4β2* nAChR(Ki=16 nM)에서 부분 작용제이고 α6β2* 및 α4α5β2 하위 유형에 대해 높은 선택성을 나타내는 새로운 콜린성 약제입니다. [3H] 시티신 부위에 대한 포자니클린의 결합 친화도(Ki, 래트)는 16.7 nM입니다.
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Cas No.: 161417-03-4
Sample solution is provided at 25 µL, 10mM.
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Pozanicline (ABT-089) selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes, is a novel cholinergic agent that is a partial agonist at α4β2* nAChRs (Ki=16 nM) and shows high selectivity for α6β2* and α4α5β2 nAChR subtypes, the binding affinity (Ki, rat) for Pozanicline to [3H] cytisine sites is 16.7 nM.Pozanicline reverses nicotine withdrawal-induced cognitive deficits, may be an effective component of novel therapeutic strategies for nicotine addiction[1]. Ki: 16 nM (α4β2* nAChR)[1]
[1]. Sullivan JP, et al. ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties. J Pharmacol Exp Ther. 1997 Oct;283(1):235-46. [2]. Yildirim E, et al. ABT-089, but not ABT-107, ameliorates nicotine withdrawal-induced cognitive deficits in C57BL6/J mice. Behav Pharmacol. 2015 Apr;26(3):241-8.
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