TH5487 |
| Catalog No.GC37776 |
TH5487은 IC50이 342nM인 강력한 8-옥소구아닌 DNA 글리코실라제 1(OGG1) 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2304947-71-3
Sample solution is provided at 25 µL, 10mM.
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TH5487 is a potent 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with an IC50 of 342 nM. TH5487 stops OGG1 from recognizing its DNA substrate, inhibits DNA repair and modifies OGG1 chromatin dynamics, which results in the inhibition of proinflammatory pathway genes[1].
TH5487 (5 μM; 1 hour) decreases TNFα- and LPS-induced proinflammatory gene expression to near pretreatment levels[1].TH5487 (0-10 μM; 1 hour) perturbs binding of NF-κB to 8-oxoG-containing synthetic DNA in nuclear extracts from MLE 12 or hSAEC cells[1]. RT-PCR[1] Cell Line: Murine airway epithelial cell line (MLE 12); Diploid human small-airway epithelial cell (hSAECs)
TH5487 (prophylactic intraperitoneally injection; 8-30 mg/kg; 1-9 hours) decreases TNFα or LPS induced the robust recruitment of neutrophils to the airways, and reduces the pulmonary neutrophil count in a time-dependent manner[1]. Animal Model: Eightweek-old female and male BALB/c mice[1]
[1]. Visnes T, et al. Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation. Science. 2018 Nov 16;362(6416):834-839.
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
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