Tubulysin F |
| Catalog No.GC37840 |
Tubulysin F는 점액박테리아 종 Archangium geophyra 및 Angiococcus disciformis에서 분리된 세포독성이 높은 펩티드입니다. Tubulysin은 더 낮은 나노몰 범위의 IC50 값으로 다중약물 내성 세포주를 포함한 포유동물 세포에서 매우 강력한 세포독성 활성을 나타냅니다. 튜불리신 F는 튜불린 중합을 억제하고 세포 주기 정지 및 세포자멸사를 유도하는 세포독성 활성 튜불리신이다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 368870-67-1
Sample solution is provided at 25 µL, 10mM.
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Tubulysin F is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range[1]. Tubulysin F is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis[2].
[1]. Kubicek K, et al. The tubulin-bound structure of the antimitotic drug tubulysin. Angew Chem Int Ed Engl. 2010 Jun 28;49(28):4809-12. [2]. Vlahov IR, et al. Acid mediated formation of an N-acyliminium ion from tubulysins: a new methodology for the synthesis of natural tubulysins and their analogs. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6778-81.
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