GDC-0853 (Synonyms: RG-7845) |
| Catalog No.GC19162 |
GDC-0853(GDC-0853)은 0.91 nM, 1.6, 1.3, 12.6, 3.4에 대해 0.91 nM, 1.6, 1.3, 12.6 및 3.4에 대해 BS에 대한 Kis를 갖는 강력하고 선택적이고 경구적으로 이용 가능한 비공유 bruton'의 티로신 키나제(Btk) 억제제입니다. , C481R, T474I, T474M 돌연변이. GDC-0853은 류마티스 관절염 및 전신성 홍반성 루푸스 연구에 대한 가능성이 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1434048-34-6
Sample solution is provided at 25 µL, 10mM.
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Fenebrutinib (GDC-0853) is a potent, selective, and noncovalent bruton's tyrosine kinase (Btk) inhibitor with a Ki of 0.91 nM.
References:
[1]. Erickson RI , et al. Bruton's Tyrosine Kinase Small Molecule Inhibitors Induce a Distinct Pancreatic Toxicity in Rats. J Pharmacol Exp Ther. 2017 Jan;360(1):226-238.
Average Rating: 5 (Based on Reviews and 15 reference(s) in Google Scholar.)
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