Gly-Arg-AMC (hydrochloride) (Synonyms: Gly-Arg-7-amino-4-methylcoumarin, GR-AMC, GR-7-amino-4-methylcoumarin) |
| Catalog No.GC45668 |
A fluorogenic substrate for cathepsin C
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 70274-78-1
Sample solution is provided at 25 µL, 10mM.
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Gly-Arg-AMC is a fluorogenic substrate for cathepsin C.1 Upon enzymatic cleavage by cathepsin C, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify cathepsin C activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.
|1. Rubach, J.K., Cui, G., Schneck, J.L., et al. The amino-acid substituents of dipeptide substrates of cathepsin C can determine the rate-limiting steps of catalysis. Biochemistry 51(38), 7551-7568 (2012).
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