GNE-375 |
| Catalog No.GC65326 |
GNE-375는 IC50이 5nM인 강력하고 고도로 선택적인 BRD9 억제제입니다. GNE-375는 BRD4, TAF1 및 CECR2에 비해 BRD9에 대해 >100배 선택성을 보여줍니다. GNE-375는 염색질에 대한 BRD9 결합을 감소시킵니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1926989-06-1
Sample solution is provided at 25 µL, 10mM.
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GNE-375 is a potent and highly selective BRD9 inhibitor with an IC50 of 5 nM. GNE-375 shows >100-fold selective for BRD9 over BRD4, TAF1, and CECR2. GNE-375 decreases BRD9 binding to chromatin[1].
[1]. Terry D Crawford, et al. Inhibition of bromodomain-containing protein 9 for the prevention of epigenetically-defined drug resistance. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3534-3541.
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