GNE-375 |
| カタログ番号GC65326 |
GNE-375 は、IC50 が 5 nM の強力で選択性の高い BRD9 阻害剤です。 GNE-375 は、BRD4、TAF1、CECR2 よりも BRD9 に対して 100 倍以上の選択性を示します。 GNE-375 は BRD9 のクロマチンへの結合を減少させます。
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Cas No.: 1926989-06-1
Sample solution is provided at 25 µL, 10mM.
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GNE-375 is a potent and highly selective BRD9 inhibitor with an IC50 of 5 nM. GNE-375 shows >100-fold selective for BRD9 over BRD4, TAF1, and CECR2. GNE-375 decreases BRD9 binding to chromatin[1].
[1]. Terry D Crawford, et al. Inhibition of bromodomain-containing protein 9 for the prevention of epigenetically-defined drug resistance. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3534-3541.
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