GSK840 (Synonyms: GSK'840) |
Catalog No.GC34605 |
GSK840(GSK'840)은 0.9nM의 IC50으로 RIP3 키나제 도메인에 결합하고 0.3nM의 IC50으로 키나제 활성을 억제하는 수용체 상호작용 단백질 키나제 3(RIP3 또는 RIPK3) 억제제입니다.
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Cas No.: 2361146-30-5
Sample solution is provided at 25 µL, 10mM.
GSK840 (GSK’840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 0.9 nM, and inhibits kinase activity with an IC50 of 0.3 nM[1]. IC50: 0.3 nM (RIP3)[1]
Reference:
[1]. Mandal P, et al. RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol Cell. 2014 Nov 20;56(4):481-95.
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