HaloPROTAC 2 (Synonyms: HaloPROTAC 2) |
| Catalog No.GC32831 |
HaloPROTAC 2(HaloPROTAC 2)는 E3 및 21개 원자 길이 링커에 대한 리간드의 접합체입니다. 링커의 커넥터는 할로겐 그룹입니다. HaloPROTAC 2는 VH032 기반 VHL 리간드 및 5-유닛 PEG 링커를 통합합니다. HaloPROTAC 2는 세포 기반 분석에서 GFP-HaloTag7의 분해를 유도할 수 있습니다.
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Cas No.: 1799506-06-1
Sample solution is provided at 25 µL, 10mM.
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HaloPROTAC 2, a chloroalkane-containing PROTAC, induces degradation of HaloTag fusion proteins.
HaloPROTAC 1 and HaloPROTAC2, containing different linker lengths, are synthesized. Their ability to degrade GFP-HaloTag7, (stably expressed in HEK 293 cells) is tested tby flow cytometry, measuring changes in mean fluorescence intensity. While 24 hour treatment with HaloPROTAC 1 leads to less than 20% degradation, the longer HaloPROTAC2 leads to nearly 70% degradation of GFP-Halotag7 at 2.5 μM[1].
[1]. Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chem Biol. 2015 Aug 21;10(8):1831-7.
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