IU1-248 |
| Catalog No.GC63027 |
IU1의 유도체인 IU1-248은 IC50이 0.83μM인 강력하고 선택적인 USP14 억제제입니다.
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Cas No.: 2307472-03-1
Sample solution is provided at 25 µL, 10mM.
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IU1-248, a derivative of IU1, is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM.
IU1-248 exhibits an IC50 value of 0.83 μM toward USP14, which is comparable to that of IU1-47 (IC50=0.68 μM) and 10-fold more potent than that of IU1 (IC50=12.25 μM)[1].
[1]. Yiwei Wang, et al. Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade. Cell Res. 2018 Dec;28(12):1186-1194.
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