JTE 607 dihydrochloride |
| Catalog No.GC50117 |
고도로 선택적인 염증성 사이토카인 합성 억제제인 JTE 607 이염산염은 생쥐의 내독소 쇼크로부터 보호합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 188791-09-5
Sample solution is provided at 25 µL, 10mM.
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Cytokine release inhibitor. Inhibits production of IL-1β, IL-8, IL-6, IL-10 and TNFα (IC50 values are 5.9, 7.3, 8.8, 9.1 and 11.0 nM, respectively) from LPS-stimulated PBMCs. Reduces proinflammatory cytokine-release and attenuates lung permeability in a rat lung injury model. Induces apoptosis in leukemia cells in vitro and prolongs survival in a mouse leukemia model.
Kakutani et al (1999) JTE-607, a novel inflammatory cytokine synthesis inhibitor without immunosuppression, protects from endotoxin shock in mice. Inflamm.Res. 48 461 PMID:10493164 |Jian (2004) JTE-607, a cytokine release blocker, attenuates acid aspiration-induced lung injury in rats. Eur.J.Pharmacol. 488 231 PMID:15044056 |Tajima et al (2010) JTE-607, a multiple cytokine production inhibitor, induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells. Cancer Sci. 101 774 PMID:20028380
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
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