>>Signaling Pathways>> Antibody-drug Conjugate/ADC Related>> ADC Linker>>Mc-Val-Cit-PAB-Cl

Mc-Val-Cit-PAB-Cl

Catalog No.GC61034

Mc-Val-Cit-PAB-Cl은 절단 가능한 ADC 링커입니다. Mc-Val-Cit-PAB-Cl은 MMAE와 항체를 접합하여 항체-MC-vc-MMAE를 형성하는 데 사용할 수 있습니다(예: BJAB의 경우 IC50이 3.3 및 0.95nM인 항-CD22-MC-VC-PABC-MMAE 및 세포독성 분석에서 WSU 세포주).

Products are for research use only. Not for human use. We do not sell to patients.

Mc-Val-Cit-PAB-Cl Chemical Structure

Cas No.: 1639351-92-0

Size 가격 재고 수량
100mg
US$1,854.00
재고 있음

Tel:(909) 407-4943 Email: sales@glpbio.com

고객 리뷰

Based on customer reviews.

  • GlpBio Citations

    GlpBio Citations
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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

Mc-Val-Cit-PAB-Cl is a cleavable ADC linker. Mc-Val-Cit-PAB-Cl can be used to conjugate MMAE and antibody to form antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE with IC50s of 3.3 and 0.95 nM for BJAB and WSU cell lines in cytotoxicity assay).

[1]. Staben LR, et al. Stabilizing a Tubulysin Antibody-Drug Conjugate To Enable Activity Against Multidrug-Resistant Tumors. ACS Med Chem Lett. 2017 Sep 5;8(10):1037-1041.

리뷰

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Average Rating: 5 ★★★★★ (Based on Reviews and 24 reference(s) in Google Scholar.)

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