Mc-Val-Cit-PAB-Cl |
Catalog No.GC61034 |
Mc-Val-Cit-PAB-Cl은 절단 가능한 ADC 링커입니다. Mc-Val-Cit-PAB-Cl은 MMAE와 항체를 접합하여 항체-MC-vc-MMAE를 형성하는 데 사용할 수 있습니다(예: BJAB의 경우 IC50이 3.3 및 0.95nM인 항-CD22-MC-VC-PABC-MMAE 및 세포독성 분석에서 WSU 세포주).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1639351-92-0
Sample solution is provided at 25 µL, 10mM.
Mc-Val-Cit-PAB-Cl is a cleavable ADC linker. Mc-Val-Cit-PAB-Cl can be used to conjugate MMAE and antibody to form antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE with IC50s of 3.3 and 0.95 nM for BJAB and WSU cell lines in cytotoxicity assay).
[1]. Staben LR, et al. Stabilizing a Tubulysin Antibody-Drug Conjugate To Enable Activity Against Multidrug-Resistant Tumors. ACS Med Chem Lett. 2017 Sep 5;8(10):1037-1041.
Average Rating: 5
(Based on Reviews and 24 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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