K-Ras ligand-Linker Conjugate 5 |
| Catalog No.GC39225 |
K-Ras 리간드-링커 접합체 5는 K-Ras 모집 부분에 대한 리간드와 E3 리가제(예: VHL, CRBN, MDM2 및 IAP)를 모집하는 PROTAC 링커를 통합합니다. K-Ras 리간드-링커 접합체 5는 SW1573 세포에서 ≥70% 분해 효능을 나타내는 강력한 PROTAC K-Ras 분해제인 PROTAC K-Ras 분해기-1의 합성에 사용할 수 있습니다.
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Cas No.: 2378261-85-7
Sample solution is provided at 25 µL, 10mM.
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K-Ras ligand-Linker Conjugate 5 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 5 can be used in the synthesis of PROTAC K-Ras Degrader-1 , which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].
[1]. CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2.
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