Kobophenol A |
Catalog No.GC64263 |
올리고머 스틸벤인 코보페놀 A는 1.81μM의 IC50으로 ACE2 수용체와 S1-RBD 사이의 상호작용을 차단하고 71.6μM의 EC50으로 세포에서 SARS-CoV-2 바이러스 감염을 억제합니다.
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Cas No.: 124027-58-3
Sample solution is provided at 25 µL, 10mM.
Kobophenol A, an oligomeric stilbene, blocks the interaction between the ACE2 receptor and S1-RBD with an IC50 of 1.81 μM and inhibits SARS-CoV-2 viral infection in cells with an EC50 of 71.6 μM. Kobophenol A inhibits the activity of partially purified rat brain protein kinase C (PKC) with an IC50 of 52 µM[1][2].
[1]. Gangadevi S, et al. Kobophenol A Inhibits Binding of Host ACE2 Receptor with Spike RBD Domain of SARS-CoV-2, a Lead Compound for Blocking COVID-19. J Phys Chem Lett. 2021;12(7):1793-1802.
[2]. Xu G, Zhang LP, Chen LF, Hu CQ. Yao Xue Xue Bao. 1994;29(11):818-822.
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