LDN-91946 |
| Catalog No.GC60981 |
LDN-91946은 2.8μM의 Ki 앱을 갖는 강력하고 선택적이고 비경쟁적인 유비퀴틴 C-말단 가수분해효소-L1(UCH-L1) 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 439946-22-2
Sample solution is provided at 25 µL, 10mM.
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LDN-91946 is a potent, selective and uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with a Ki app of 2.8 μM[1].
LDN-91946 is inactive against UCH-L3 at 20 μM. LDN-91946 demonstrates no activity against TGase 2, Papain, and Caspase-3 at 40 μM[1]. There is no cytotoxicity when serum-starved Neuro 2A (N2A) cells are treated with LDN-91946 at concentrations as high as 0.1 mM[1].
[1]. Mermerian AH, et al. Structure-activity relationship, kinetic mechanism, and selectivity for a new class of ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitors. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3729-32.
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