Ligustroside |
| Catalog No.GC63973 |
세코이리도이드 유도체인 리구스트로사이드(리그스트로사이드)는 Aβ 생성을 방해하지 않을 수 있는 메커니즘에 의해 초기 알츠하이머병(AD) 및 뇌 노화 모델에서 미토콘드리아 생체 에너지에 탁월한 성능을 보입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 35897-92-8
Sample solution is provided at 25 µL, 10mM.
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Ligustroside (Ligstroside), a secoiridoid derivative, has outstanding performance on mitochondrial bioenergetics in models of early Alzheimer’s disease (AD) and brain ageing by mechanisms that may not interfere with Aβ production. Ligustroside significantly inhibits nitric oxide production in lipopolysaccharide-activated RAW264.7 macrophages[1][2].
Ligstroside increases mRNA expression of SIRT1, CREB1, complex I, and GPx1 in SH-SY5Y-APP695 cells[1].
Ligstroside (50 mg/kg; a supplemented diet for 6 months) protects against mitochondrial dysfunction in models of early Alzheimer’s disease and brain ageing[1].
[1]. Grewal R, et al. Purified oleocanthal and ligstroside protect against mitochondrial dysfunction in models of early Alzheimer’s disease and brain ageing. Exp Neurol. 2020;328:113248. [2]. Liu J, et al. Chemical structures of constituents from the flowers of Osmanthus fragrans var. aurantiacus. J Nat Med. 2015;69(1):135-141.
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