Loreclezole |
| Catalog No.GC14045 |
항간질제 화합물인 로레클레졸은 선택적 GABAA 수용체 조절제로 수용체를 포함하는 β2 또는 β3-소단위체의 양성 알로스테릭 조절제로 작용합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 117857-45-1
Sample solution is provided at 25 µL, 10mM.
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Loreclezole, an antiepileptic compound, is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors[1][2].
References:
[1]. Wingrove PB, et al. The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit. Proc Natl Acad Sci U S A. 1994 May 10;91(10):4569-73.
[2]. Sanna E, et al. Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit. Neuropharmacology. 1996;35(12):1753-60.
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