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Loreclezole

Catalog No.GC14045

GABAA receptor modulator

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Loreclezole Chemical Structure

Cas No.: 117857-45-1

Size Price Stock Qty
10mg
$167.00
Ship Within 7 Days
50mg
$640.00
Ship Within 7 Days

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

Loreclezole, an antiepileptic compound, is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors[1][2].

References:
[1]. Wingrove PB, et al. The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit. Proc Natl Acad Sci U S A. 1994 May 10;91(10):4569-73.
[2]. Sanna E, et al. Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit. Neuropharmacology. 1996;35(12):1753-60.

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