Malabaricone C (Synonyms: NSC 287968)

Malabaricone C is a diarylnonanoid that has been found in Myristica and has diverse biological activities.1,2,3,4 It scavenges 59.9% of 2,2-diphenyl-1-picrylhydrazyl radicals when used at a concentration of 7 μg/ml.1 Malabaricone C is active against S. aureus, B. subtilis, and C. albicans in vitro (MICs = 2-32 μg/ml).2 It is cytotoxic to A549, HL-60, and MCF-7 cells (IC50s = 12.3, 46.1, and 10.8 μM, respectively).3 Malabaricone C inhibits sphingomyelin synthase 1 (SMS1) and SMS2 activity in cell lysates (IC50s = 3 and 1.5 μM, respectively).4 It decreases body weight gain, hepatic steatosis, and hepatic and plasma triglyceride levels in a mouse model of high-fat diet-induced obesity when administered at a dose of 0.1% in the diet.

|1. Patro, B.S., Bauri, A.K., Mishra, S., et al. Antioxidant activity of Myristica malabarica extracts and their constituents. J. Agric. Food Chem. 53(17), 6912-6918 (2005).|2. Orabi, K.Y., Mossa, J.S., and El-Feraly, F.S. Isolation and characterization of two antimicrobial agents from mace (Myristica fragrans). J. Nat. Prod. 54(3), 856-859 (1991).|3. Cuong, T.D., Lim, C.J., Trang, T.T.T., et al. Compounds from the seeds of Myristica fragrans and their cytotoxic activity. Nat. Prod. Sci. 18(2), 97-101 (2012).|4. Othman, M.A., Yuyama, K., Murai, Y., et al. Malabaricone C as natural sphingomyelin synthase inhibitor against diet-induced obesity and its lipid metabolism in mice. Med. Chem. Lett. 10(8), 1154-1158 (2019).