Mc-Val-Cit-PAB-Cl |
| Katalog-Nr.GC61034 |
Mc-Val-Cit-PAB-Cl ist ein spaltbarer ADC-Linker. Mc-Val-Cit-PAB-Cl kann verwendet werden, um MMAE und AntikÖrper zu konjugieren, um AntikÖrper-MC-vc-MMAE zu bilden (z. B. Anti-CD22-MC-VC-PABC-MMAE mit IC50s von 3,3 und 0,95 nM fÜr BJAB und WSU-Zelllinien im ZytotoxizitÄtsassay).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1639351-92-0
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Mc-Val-Cit-PAB-Cl is a cleavable ADC linker. Mc-Val-Cit-PAB-Cl can be used to conjugate MMAE and antibody to form antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE with IC50s of 3.3 and 0.95 nM for BJAB and WSU cell lines in cytotoxicity assay).
[1]. Staben LR, et al. Stabilizing a Tubulysin Antibody-Drug Conjugate To Enable Activity Against Multidrug-Resistant Tumors. ACS Med Chem Lett. 2017 Sep 5;8(10):1037-1041.
Average Rating: 5 (Based on Reviews and 24 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *