N-Boc-PEG4-bromide |
Catalog No.GC61616 |
N-Boc-PEG4-bromide는 PEG/Alkyl/ether 기반 PROTAC 링커로 PROTAC 합성에 사용할 수 있습니다. N-Boc-PEG4-bromide는 항체-약물 접합체(ADC) 합성에 사용되는 절단 가능한 ADC 링커입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1076199-21-7
Sample solution is provided at 25 µL, 10mM.
N-Boc-PEG4-bromide is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG4-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
[1]. Jan Anderl, et al. Amatoxin-Conjugates with Improved Linkers. US20130259880A1
Average Rating: 5
(Based on Reviews and 30 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *