N,N'-Dimethylthiourea |
| Catalog No.GC61644 |
Allii Sativi Bulbus에서 분리된 N,N'-Dimethylthiourea(DMTU)는 히드록실 라디칼(•OH)의 경구 활성 제거제이며 시험관 내에서 활성화된 호중구에 의한 OH 생성을 차단합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 534-13-4
Sample solution is provided at 25 µL, 10mM.
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N,N'-Dimethylthiourea (DMTU), isolated from Allii Sativi Bulbus, is an orally active scavenger of hydroxyl radical (•OH) and blocks •OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects against water-immersion restraint stress (WIRS)-induced gastric mucosal lesions in rats by exerting its antioxidant action including •OH scavenging and anti-inflammatory action[1][2].
N,N'-Dimethylthiourea (DMTU; 1, 2.5, or 5 mmol/kg; orally) administered at 0.5 h before the onset of WIRS reduces the severity of gastric mucosal lesions with attenuation of the changes in the levels of gastric mucosal MPO, pro-inflammatory cytokines, LPO, NOx, nonprotein SH, and vitamin C and gastric adherent mucus found at 3 h after the onset of WIRS in a dose-dependent manner in Male Wistar rats aged 6 weeks[1].
[1]. Yoshiji Ohta, et al. Protective effect of N,N'-dimethylthiourea against stress-induced gastric mucosal lesions in rats. Fundam Clin Pharmacol. 2017 Jun;31(3):319-328. [2]. Zhongyi Zhang, et al. Analysis of volatile compounds in fermented black garlic by GC-MS.
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