N-Palmitoyl Glycine (Synonyms: NHexadecanoylGlycine, PalGly) |
| Catalog No.GC44456 |
N-팔미토일 글리신(N-팔미토일 글리신)은 감각 뉴런에서 칼슘 유입과 산화질소(NO) 생성의 조절자 역할을 하는 내인성 지질입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2441-41-0
Sample solution is provided at 25 µL, 10mM.
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The acyl amides are a family of endogenous lipids that act as potent modulators of pain and inflammation. The best characterized members of this family are the arachidonoyl amides, which includes N-arachidonoyl ethanolamide (AEA; anandamide). N-palmitoyl glycine (PalGly) contains an 18-carbon saturated fatty acid that is amide-linked to glycine and is structurally similar to the phospholipid-derived N-acyl ethanolamines. Endogenously produced in rat skin and spinal cord, PalGly is present in 100-fold greater amounts in skin and 3-fold greater in brain compared to AEA. Injection of 0.43 µg PalGly in rat hindpaw inhibits heat-induced firing of nociceptive neurons in rat dorsal horn. PalGly treatment induces transient calcium influx in native dorsal root ganglion (DRG) cells and in the PTX-sensitive, DRG-like cell line F-11 (EC50 = 5.5 µM).
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