NDI-034858 |
| Catalog No.GC66329 |
NDI-034858은 TYK2 억제제로, 결합 상수 Kd가 200pM 미만인 TYK2 JH2 도메인을 표적으로 합니다.821d96072c2d58d8970e76f526b0f6b8
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Cas No.: 2272904-53-5
Sample solution is provided at 25 µL, 10mM.
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NDI-034858 is a TYK2 inhibitor, target TYK2 JH2 domain with binding constant Kd of <200 pM[1].
NDI-034858 (compound I-908) (10 μM) exhibits inhibitory effect on Tyk2 and JAK by targeting Tyk2 JH1 and JAK JH1 domain with inhibition rates <50%, respectively[1].
NDI-034858 inhibits phosphorylation induction of heterodimer complex Tyk2 /JAK2-mediated IL-12 (1.7 ng/mL) effect, with IC50 value of <0.1 μM in human peripheral blood mononuclear cell[1].
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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