PF 06260933 dihydrochloride |
| Catalog No.GC50252 |
MAP4K4 (HGK) inhibitor; also inhibits MINK and TNIK
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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MAP4K4 (HGK) inhibitor (IC50 = 140 nM). Also inhibits MINK and TNIK (IC50 values are 8 and 13 nM, respectively). Improves fasting hyperglycemia in mice. Orally active.
Ammirati et al (2015) Discovery of an in vivo tool to establish proof-of-concept for MAP4K4-based antidiabetic treatment. ACS Med.Chem.Lett. 6 1128 PMID:26617966
Review for PF 06260933 dihydrochloride
Average Rating: 5 (Based on Reviews and 17 reference(s) in Google Scholar.)
Review for PF 06260933 dihydrochloride
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