Procyclidine hydrochloride ((±)-Procyclidine hydrochlorid) |
| Catalog No.GC30946 |
항콜린제인 Procyclidine(Tricyclamol, ()-Procyclidine) hydrochloride는 N-methyl-D-aspartate(NMDA) 길항제의 특성을 갖는 무스카린 수용체 길항제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1508-76-5
Sample solution is provided at 25 µL, 10mM.
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Procyclidine hydrochloride is a potent anti-cholinergic agent, and is also known to have NMDA antagonist properties.
Procyclidine widely used as anti-parkinsonian agents because of their anti-cholinergic action, is also known to have NMDA antagonist properties. Unlike other NMDA antagonists, these agents-because of their anti-cholinergic action-are devoid of neurotoxic side effects. Procyclidine alleviates thermal hyperalgesia in a dose dependent manner; when a marginally effective dose of the agent is combined with an ineffective dose of an alpha(2) adrenergic agonist (Clonidine or Guanabenz), the combination therapy provides effective and long-lasting relief from neuropathic pain[1].
[1]. Jevtovic-Todorovic V, et al. Anti-parkinsonian agents procyclidine and ethopropazine alleviate thermal hyperalgesia in neuropathic rats. Neuropharmacology. 2003 May;44(6):739-48.
Average Rating: 5 (Based on Reviews and 9 reference(s) in Google Scholar.)
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