Procyclidine hydrochloride ((±)-Procyclidine hydrochlorid) |
| Catalog No.GC30946 |
Procyclidine (Tricyclamol, (±)-Procyclidine) hydrochloride , an anticholinergic agent, is a muscarinic receptor antagonist that also has the properties of an N-methyl-D-aspartate (NMDA) antagonist.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1508-76-5
Sample solution is provided at 25 µL, 10mM.
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Procyclidine hydrochloride is a potent anti-cholinergic agent, and is also known to have NMDA antagonist properties.
Procyclidine widely used as anti-parkinsonian agents because of their anti-cholinergic action, is also known to have NMDA antagonist properties. Unlike other NMDA antagonists, these agents-because of their anti-cholinergic action-are devoid of neurotoxic side effects. Procyclidine alleviates thermal hyperalgesia in a dose dependent manner; when a marginally effective dose of the agent is combined with an ineffective dose of an alpha(2) adrenergic agonist (Clonidine or Guanabenz), the combination therapy provides effective and long-lasting relief from neuropathic pain[1].
[1]. Jevtovic-Todorovic V, et al. Anti-parkinsonian agents procyclidine and ethopropazine alleviate thermal hyperalgesia in neuropathic rats. Neuropharmacology. 2003 May;44(6):739-48.
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