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Procyclidine hydrochloride ((±)-Procyclidine hydrochlorid) Catalog No.GC30946

Size Price Stock Qty
10mM*1mLinDMSO
$71.00
In stock
100mg
$65.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Quality Control

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Protocol

Animal experiment:

Rats[1] Adult Sprague-Dawley female rats (weight 300-330 g) are used. Procyclidine given systemically causes a transient increase in locomotor activity (mainly non-ambulatory fine movements) in adult rats. Locomotor activity data (ambulations, fine movements) are evaluated using a two-way ANOVA to test whether co-administration of clonidine (0.025 mg/kg) with various doses of Procyclidine (10, 25, 50 and 75 mg/kg) altered the activity levels compared to the same doses of Procyclidine administered alone. A one-way ANOVA and subsequent comparisons are also conducted to establish whether the activity levels for each treatment group are different from saline controls.

References:

[1]. Jevtovic-Todorovic V, et al. Anti-parkinsonian agents procyclidine and ethopropazine alleviate thermal hyperalgesia in neuropathic rats. Neuropharmacology. 2003 May;44(6):739-48.

Chemical Properties

Cas No. 1508-76-5 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES OC(C1=CC=CC=C1)(C2CCCCC2)CCN3CCCC3.[H]Cl
Formula C19H30ClNO M.Wt 323.9
Solubility DMSO : 10.66 mg/mL (32.91 mM; Need ultrasonic and warming) Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

Procyclidine hydrochloride is a potent anti-cholinergic agent, and is also known to have NMDA antagonist properties.

Procyclidine widely used as anti-parkinsonian agents because of their anti-cholinergic action, is also known to have NMDA antagonist properties. Unlike other NMDA antagonists, these agents-because of their anti-cholinergic action-are devoid of neurotoxic side effects. Procyclidine alleviates thermal hyperalgesia in a dose dependent manner; when a marginally effective dose of the agent is combined with an ineffective dose of an alpha(2) adrenergic agonist (Clonidine or Guanabenz), the combination therapy provides effective and long-lasting relief from neuropathic pain[1].

[1]. Jevtovic-Todorovic V, et al. Anti-parkinsonian agents procyclidine and ethopropazine alleviate thermal hyperalgesia in neuropathic rats. Neuropharmacology. 2003 May;44(6):739-48.