PTP1B Inhibitor (Synonyms: Protein Tyrosine Phosphatase 1B Inhibitor) |
Catalog No.GC44775 |
PTP1B 억제제는 IC50이 8 μ인 단백질 티로신 포스파타제 PTP1B의 비경쟁적 알로스테릭 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 765317-72-4
Sample solution is provided at 25 µL, 10mM.
Protein tyrosine phosphatase 1B (PTP1B) has critical roles in cell signaling relevant to diabetes, obesity, and cancer. PTP1B inhibitor is a cell-permeable allosteric inhibitor of PTP1B (IC50s = 4 and 8 µM for 403 and 298 residue PTP1B forms, respectively). It binds reversibly and non-competitively, altering the conformation of the catalytic pocket. PTP1B inhibitor selectively increases the phosphorylation of the insulin receptor, insulin receptor substrate 1, and Akt, mimicking the action of insulin.
Average Rating: 5
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