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PTP1B Inhibitor (Synonyms: Protein Tyrosine Phosphatase 1B Inhibitor)

Katalog-Nr.GC44775

PTP1B Inhibitor ist ein nicht-kompetitiver allosterischer Inhibitor der Proteintyrosinphosphatase PTP1B mit einem IC50 von 8 μM.

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PTP1B Inhibitor Chemische Struktur

Cas No.: 765317-72-4

Größe Preis Lagerbestand Menge
500μg
45,00 $
Auf Lager
1mg
81,00 $
Auf Lager
5mg
235,00 $
Auf Lager
10mg
387,00 $
Auf Lager

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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 1 publications

Description Chemical Properties Product Documents Related Products

Protein tyrosine phosphatase 1B (PTP1B) has critical roles in cell signaling relevant to diabetes, obesity, and cancer. PTP1B inhibitor is a cell-permeable allosteric inhibitor of PTP1B (IC50s = 4 and 8 µM for 403 and 298 residue PTP1B forms, respectively). It binds reversibly and non-competitively, altering the conformation of the catalytic pocket. PTP1B inhibitor selectively increases the phosphorylation of the insulin receptor, insulin receptor substrate 1, and Akt, mimicking the action of insulin.

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